New study reveals some benefits of orange juice

Posted: October 19, 2021 at 7:00 a.m. MDT|Update: 1 hour ago

BARTOW, Florida, October 19, 2021 / PRNewswire / – New study suggests 100% orange juice has the potential to help fight inflammation and oxidative stress in adults, paving the way for new research on the topic.

Florida Citrus Logo (PRNewsfoto / Florida Department of Citrus)

Although of limited scope, the study indicates that consuming 100% orange juice significantly reduces interleukin 6, a well-established marker of inflammation, in healthy, high-risk adults. Two additional markers of inflammatory and oxidative stress were also reduced; however, the results did not quite reach statistical significance.

The results of this study, which was funded through an unrestricted grant from the Florida Department of Citrus, align with a previously published FDOC-funded review that reported the beneficial effects of hesperidin, the major bioactive compound found in oranges and 100% orange juice, on reducing certain markers of inflammation and oxidative stress.1 Chronic inflammation can play a key role in the onset or progression of certain chronic diseases, including heart disease and diabetes.

Studies like these are needed to identify gaps in the existing evidence so that future research can be designed to specifically address these gaps. The FDOC Scientific Research Department used these findings to define the scope of work for a larger FDOC-sponsored clinical trial on the benefits of consuming 100% orange juice that is expected to begin in late 2021.

“We know that 100% orange juice contains a number of nutrients, like vitamin C, as well as beneficial bioactive compounds that have the potential to reduce inflammation and oxidative stress,” said Gail Rampersaud, registered dietitian with the Florida Citrus Department. “This review tells us that some studies find benefits with 100% orange juice, but we need more data and large, well-designed studies to draw more definitive conclusions. This review is particularly useful because we and more plans for future research related to orange juice. “

The review looked at published studies regarding 100% orange juice and markers of inflammation and oxidative stress. Led by the Think Healthy Group and researchers from Tufts University and George Mason University, the review was published in the review, Advances in Nutrition.

The analysis consisted of three parts: a qualitative review of the scope of 21 studies involving a total of 307 healthy adults and 327 adults at risk for disease; a systematic review of a subset of 16 studies that measured the six most reported biomarkers related to inflammation and oxidative stress in the body; and 10 studies that had sufficient data to conduct a meta-analysis. The researchers also looked at the overall quality and potential bias of the studies.

General and systematic reviews found that in general, 100% orange juice had either no or no (no adverse effects) effects on oxidative stress or inflammation. The researchers cautioned that the studies included a relatively small number of subjects, had low weight of evidence, and were at moderate risk of bias; therefore, overall results should be interpreted with caution.

About the Florida Department of Citrus
The Florida Department of Citrus is an executive agency of Florida government responsible for the marketing, research and regulation of Florida citrus industry. Its activities are financed by a tax paid by producers on each case of citrus fruit that passes through the commercial circuits. The industry employs over 33,000 people, has an annual economic impact of $ 6.762 billion to the state, and contributes hundreds of millions of dollars in tax revenues that help support that of Florida schools, roads and health services. For more information on the Florida Department of Citrus, please visit

The references

  1. Tadros FJ, Andrade JM. Crit Rev Food Sci Nutr. May 20, 2021: 1-20.

Media contact:
Kaitlyn karcher
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SOURCE Florida Citrus Department

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